The Biomedical Advanced Research and Development Authority (BARDA) recently entered into a nine-month, $12 million contract with Achaogen, Inc to develop an antibiotic called C-scape that could treat certain types of drug-resistant bacteria and infections caused by bacteria used in biowarfare.
Under terms of the contract, BARDA will support nonclinical studies, manufacturing, and preparatory activities for a planned Phase 3 clinical trial of C-scape to treat complicated urinary tract infections (cUTIs).
BARDA said that early testing suggested that the antibiotic could protect against biowarfare agents including the plague-causing Yersinia pestis bacteria and Francisella tularensis, which causes tularemia.
The orally-administered C-scape is being developed as a two-component treatment, combing a beta-lactam antibiotic with a compound that inhibits Extended Spectrum Beta-Lactamases enzymes.
The contract includes an extension option for up to a total of three years and $18 million to support additional manufacturing, nonclinical studies, and preparatory filings needed for approval and licensure from the U.S. Food and Drug Administration (FDA).
“Combating antibiotic-resistant infections is fundamental to U.S. biodefense,” BARDA Director Rick Bright said. “The long hospitalizations that may be likely after a bioterrorism attack leave Americans open to secondary drug-resistant infections, which means to be prepared for bioterrorism, we need to have products available that treat antibiotic-resistant infections.”
A Department of Defense (DoD) 2040 Task Force (D2T) challenge on talent management innovation drew…
For the first time since its creation in 2004, the Transportation Security Administration’s (TSA) Flight…
The 2024 Hurricane Season Campaign began for the Federal Emergency Management Agency (FEMA) this week,…
As a way to support veterans, U.S. Reps. Maria Elvira Salazar (R-FL), Dale Strong (R-AL),…
Mere days after the Department of Homeland Security formed a new Artificial Intelligence (AI) Safety…
KBR will continue to provide life support, equipment readiness, training and supply chain solutions for…
This website uses cookies.